RAPNO efforts in Brain Tumour Outcomes

Abstract

Assessing treatment efficacy for brain tumours has evolved
since its inception with the introduction of MacDonald’s
criteria, which pioneered the utility of imaging to
determine an objective and quantifiable response to
treatment. This criterion failed to distinguish pseudo
response or progression from progression and did not
account for non-enhancing disease therefore; the response
assessment in neuro-oncology (RANO) working group was
established to account for these limitations. Since, its
commencement it has worked to determine response
assessment for multiple tumours. As paediatric tumours
exhibit heterogeneous and variable-enhancing
characteristics, the response assessment in paediatric
neuro-oncology (RAPNO) working group was formed to
create separate criteria. Six response criteria have been
published to date, and the article summarizes them.
Keywords: RAPNO, neuro-oncology, response assessment