Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries

Authors

  • Mohammad Hamza Bajwa Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Muhammad Awais Khan Khyber Medical College, Peshawar, Pakistan.
  • Faiza Urooj Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Muhammad Usman Khalid Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Syed Ather Enam Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Hafiza Fatima Aziz Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Kaynat Siddiqui Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Muhammad Ehsan Bari Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Nouman Mughal Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan.

DOI:

https://doi.org/10.47391/JPMA.S3.GNO-06

Abstract

Approaches to brain tumour diagnosis and detecting
recurrence after treatment are costly and significantly
invasive. Developing peripheral-sample liquid biopsy
tools is the key to enhancing our ability to prognosticate
brain tumour subtypes and molecular heterogeneity. The
present scoping review was designed to discuss current
updates in liquid biopsy tools for diagnosis and guiding
clinical management of brain tumours; we evaluated the
literature within the context of low-and-middle-income
country challenges. Circulating tumour cells (CTCs),
circulating tumour DNA (ctDNA), cell-free DNA (cfDNA),
extracellular vesicle-associated biomarkers, protein
biomarkers, microRNAs, and serum metabolites are
discussed with the collation of current data supporting
their utility in liquid biopsy. Further challenges to
implanting liquid biopsy tools at a systematic level are
highlighted.
Keywords: Tumour, DNA, Neoplastic Cells, Liquid
Biopsy, Brain Neoplasms, MicroRNAs, Extracellular
Vesicles

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Published

2024-06-09

How to Cite

Mohammad Hamza Bajwa, Muhammad Awais Khan, Faiza Urooj, Muhammad Usman Khalid, Syed Ather Enam, Hafiza Fatima Aziz, Kaynat Siddiqui, Muhammad Ehsan Bari, & Nouman Mughal. (2024). Serum liquid biopsy for brain tumours: a scoping analysis of practicable approaches in low- and middle-income countries. Journal of the Pakistan Medical Association, 74(3 (Supple), S30-S50. https://doi.org/10.47391/JPMA.S3.GNO-06

Issue

Vol. 74 No. 3 (Supple) (2024): AKU Special Supplement: Global Neuro-Oncology

Section

Narrative Review.

License

Copyright (c) 2024 Journal of the Pakistan Medical Association

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This work is licensed under a Creative Commons Attribution 4.0 International License.