Consensus guidelines for the management of primary central nervous system lymphoma for low and middle-income countries

Authors

  • Hafiza Fatima Aziz Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Saqib Kamran Bakhshi Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Noman Ahmed Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Mohammad Hamza Bajwa Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Adnan Abdul Jabbar Department of Oncology, Ziauddin University Hospital, Karachi, Pakistan.
  • Asim Hafiz Department of Radiation Oncology, The Aga Khan University, Karachi, Pakistan.
  • Ahmed Gilani Department of Pathology, University of Colorado, Children's Hospital Colorado, USA.
  • Muhammad Usman Khalid Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Pakistan Brain Tumour Consortium: (Authors list at the end of the supplement) +92 (021) 32226443
  • Syed Ather Enam Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan

DOI:

https://doi.org/10.47391/JPMA.S3.GNO-20

Abstract

Primary lymphoma of the central nervous system (PCNSL)
is a rare and aggressive form of extranodal non-Hodgkin
lymphoma primarily involving the brain, spinal cord,
cerebrospinal fluid, and eyes. The role of surgical
intervention in PCNSL is currently limited to biopsy and
decompression of critical structures if needed – extended
resection is debated. Chemotherapy is the mainstay of
treatment. In lower and middle-income countries (LMICs),
issues like delayed diagnosis and resource constraints are
widespread. These guidelines provide a framework for
addressing PCNSL in LMICs, emphasizing the importance
of early diagnosis, tailored treatment approaches, and
ongoing patient monitoring to improve outcomes for this
rare and aggressive disease.
Keywords: Lymphoma, non-Hodgkin, biopsy, nervous
system, physiologic decompression, spinal cord, brain
tumours

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Published

2024-06-09

How to Cite

Hafiza Fatima Aziz, Saqib Kamran Bakhshi, Noman Ahmed, Mohammad Hamza Bajwa, Adnan Abdul Jabbar, Asim Hafiz, Ahmed Gilani, Muhammad Usman Khalid, Pakistan Brain Tumour Consortium: (Authors list at the end of the supplement), & Syed Ather Enam. (2024). Consensus guidelines for the management of primary central nervous system lymphoma for low and middle-income countries. Journal of the Pakistan Medical Association, 74(3 (Supple), S168-S176. https://doi.org/10.47391/JPMA.S3.GNO-20

Issue

Vol. 74 No. 3 (Supple) (2024): AKU Special Supplement: Global Neuro-Oncology

Section

NARRATIVE REVIEW

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Copyright (c) 2024 Journal of the Pakistan Medical Association

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This work is licensed under a Creative Commons Attribution 4.0 International License.