Consensus guidelines for the management of adult low-grade gliomas for low and middle-income countries

Authors

  • Ahsan Ali Khan Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Ayesha Akbar Waheed The Aga Khan Medical College and University, Karachi, Pakistan.
  • Ali Azan Ahmed The Aga Khan Medical College and University, Karachi, Pakistan.
  • Asim Hafiz Department of Radiation Oncology, The Aga Khan University, Karachi, Pakistan.
  • Adeeba Zaki Department of Oncology, Aga Khan University Hospital, Pakistan.
  • Ahmed Gilani Department of Pathology, University of Colorado, Children's Hospital Colorado, USA.
  • Faiza Urooj The Aga Khan Medical College and University, Karachi, Pakistan.
  • Mohammad Hamza Bajwa Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.
  • Pakistan Brain Tumour Consortium: (Authors list at the end of the supplement)
  • Syed Ather Enam Department of Neurosurgery, The Aga Khan University, Karachi, Pakistan.

DOI:

https://doi.org/10.47391/JPMA.S3.GNO-11

Abstract

Low-grade gliomas (LGG) are brain tumors of glial cells
origin. They are grade 1 and grade 2 tumors according to
the WHO classification. Diagnosis of LGG is made through
imaging, histopathological analysis, and use of molecular
markers. Imaging alone does not establish the grade of
the tumor and thus a histopathological examination of
tissue is crucial in establishing the definite
histopathological diagnosis. Clinical presentation varies
according to the location and size of the tumor. Surgical
resection is strongly recommended in LGG over
observation to improve overall survival as surgery leads to
greater benefit due to progression-free survival. Radiation
has shown benefits in LGG patients in randomized
controlled trials and chemotherapy with temozolomide
has also shown good results. This paper covers the
principles of low-grade gliomas management and
summarizes the recommendations for the LMICs.
Keywords: Temozolomide, survival, brain Neoplasms,
glioma, neuroglia

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Published

2024-06-09

How to Cite

Ahsan Ali Khan, Ayesha Akbar Waheed, Ali Azan Ahmed, Asim Hafiz, Adeeba Zaki, Ahmed Gilani, Faiza Urooj, Mohammad Hamza Bajwa, Pakistan Brain Tumour Consortium: (Authors list at the end of the supplement), & Syed Ather Enam. (2024). Consensus guidelines for the management of adult low-grade gliomas for low and middle-income countries. Journal of the Pakistan Medical Association, 74(3 (Supple), S93-S99. https://doi.org/10.47391/JPMA.S3.GNO-11

Issue

Vol. 74 No. 3 (Supple) (2024): AKU Special Supplement: Global Neuro-Oncology

Section

NARRATIVE REVIEW

License

Copyright (c) 2024 Journal of the Pakistan Medical Association

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This work is licensed under a Creative Commons Attribution 4.0 International License.