Triglyceride glucose index can predict the risk of contrast-induced nephropathy undergoing percutaneous coronary intervention: a systematic review and meta-analysis

Abstract

Objective: To investigate the association between triglyceride glucose index and contrast-induced nephropathy in patients after percutaneous coronary intervention.

Methods: The meta-analysis was conducted in Ningbo in 2024 from May to July and comprised literature search across PubMed, Embase and Web of Science databases for relevant studies published up to May 2024 and evaluated the adverse outcomes of contrast-induced nephropathy in patients after percutaneous coronary intervention. The pooled odds ratios with 95% confidence intervals were calculated by random-effects model, assessing the strength of association between triglyceride glucose index and contrast-induced nephropathy. Subgroup analysis assessed the sources of heterogeneity. Data was analysed using Stata 17.

Results: Of the 212 studies identified initially, 6(2.8%) were included, comprising 4,521individuals; 2,996(66.3%) men and 1,525(33.7%) women. High triglyceride glucose index increased the risk of contrast-induced nephropathy in the patients compared to those with low triglyceride glucose index (p<0.05). There was a significant association between triglyceride glucose index and an increased risk of contrast-induced nephropathy (p=0.012). There was some obvious heterogeneity in the meta-analysis (I²=79.9%).

Conclusion: Triglyceride glucose index in patients undergoing percutaneous coronary intervention was found to be associated with marked increase in the risk of contrast-induced nephropathy. Pretreatment of high-risk patients could reduce the risk.

Key Words: Triglyceride glucose index, Contrast-induced nephropathy, Meta-analysis, Percutaneous coronary intervention, Predictor.