The 4BE quinqunx: A model for obesity pathogenesis

Abstract

For obesity management to be effective, one must
appreciate its causes and consequences. To do so, the
seemingly complex science of obesity must be made
simpler. A model which helps us explain its causes,
contributory factors, as well as potential corrective
measures, is needed. We share the 4BE winged quincunx
model of obesity etiopathogenesis. Four central players -
the Brain, Bowel, Beta/alpha cell and Bulk (adipose tissue)-
form a causative quadruple, with four wings-
Environmental determinants, Endocrine factors, Enteric
microbiome and Extraneous limitations. The centre of the
quincunx is occupied, in a stylish manner, by the ABC of
weight management: Attitude, Behaviour and Choices.
The 4BE concept makes it easy for health care
professionals to understand, and explain, obesity.
KEYWORDS: Biochemistry, endocrinology, obesity,
overweight, pathogenesis, person centred care,
therapeutic patient education