Role of 68Ga-DOTA-TOC PET/CT in the Evaluation of Meningiomas with Osseous Involvement

Abstract

Meningiomas with osseous involvement present unique
diagnostic and therapeutic challenges due to their variable
patterns of bone remodelling, hyperostosis, and direct
bone infiltration. While MRI and CT remain the standard
imaging modalities for evaluating soft-tissue extension and
bony architecture respectively, they often fall short in
accurately distinguishing true tumour invasion from
reactive changes, particularly in complex skull-base and
calvarial locations. ⁶⁸Ga-DOTA-TOC PET/CT represents a
pivotal advancement in the imaging of meningiomas with
osseous involvement, enhancing diagnostic accuracy,
enabling multimodality management, and supporting
personalized therapeutic strategies.
Keywords: ⁶⁸Ga-DOTA PET/CT; meningiomas; radiotherapy
planning