Diagnostic value of bronchoscopy in Sars-Cov-2 infection: a systematic review Authors Hussain Ahmed Raza The Aga Khan University, Karachi, Pakistan Mohummad Hassan Raza Raja 4th Year MBBS Student, The Aga Khan University, Karachi, Pakistan Paul Arthur Bain Countway Library, Harvard Medical School, Boston, USA Harmeet Bedi Department of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, USA Rehana Salam Department of Paediatrics and Child Health, The Aga Khan University Hospital, Karachi, Pakistan Bushra Jamil Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan Majid Shafiq Department of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA DOI: https://doi.org/10.47391/JPMA.5668 Abstract Objective: To investigate the diagnostic performance of bronchoscopy in patients with coronavirus disease 2019 infection. Method: The systematic review was conducted in April 2021 and comprised search of published articles and preprint servers for original articles assessing diagnostic performance of bronchoscopy in patients with suspected coronavirus disease 2019 infection. The primary outcome of interest was diagnostic sensitivity of bronchoalveolar lavage in the patients The quality of each study was assessed using the Quality Assessment, Data Abstraction and Synthesis-2 tool. Results: Of the 29 full-text articles assessed for eligibility, 4(13.8%) were included collectively comprising 209 patients who had undergone bronchoalveolar lavage. Mean sensitivity of bronchoalveolar lavage was 83.5% +/- 10.63 (range: 68.2-940%). Overall, the 4 studies had an unclear or low risk of bias. Conclusion: Limited data suggested that bronchoscopy with bronchoalveolar lavage did not have reliably higher diagnostic sensitivity than that reported for either nasopharyngeal or oropharyngeal swabs. Key Words: Bronchoscopy and interventional techniques, COVID-19, Diagnostic techniques. Author Biography Harmeet Bedi, Department of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, USA Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA, USA Downloads Full Text Article Published 2022-12-15 How to Cite Raza, H. A., Raja, M. H. R., Bain, P. A., Bedi, H., Salam, R., Jamil, B., & Shafiq, M. (2022). Diagnostic value of bronchoscopy in Sars-Cov-2 infection: a systematic review. Journal of the Pakistan Medical Association, 73(1), 98–105. https://doi.org/10.47391/JPMA.5668 More Citation Formats ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver Download Citation Endnote/Zotero/Mendeley (RIS) BibTeX Issue Vol. 73 No. 1 (2023): JANUARY Section Systematic Reviews